Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins

Hila Winer; Milana Fraiberg; Adi Abada; Tali Dadosh; Bat-Chen Tamim-Yecheskel; Zvulun Elazar

doi:10.1038/s41467-018-06275-1

Nature Communications (Sep 2018)

Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins

Hila Winer,
Milana Fraiberg,
Adi Abada,
Tali Dadosh,
Bat-Chen Tamim-Yecheskel,
Zvulun Elazar

Affiliations

Hila Winer: Department of Biomolecular Sciences, The Weizmann Institute of Science
Milana Fraiberg: Department of Biomolecular Sciences, The Weizmann Institute of Science
Adi Abada: Department of Biomolecular Sciences, The Weizmann Institute of Science
Tali Dadosh: Department of Chemical Research Support, The Weizmann Institute of Science
Bat-Chen Tamim-Yecheskel: Department of Biomolecular Sciences, The Weizmann Institute of Science
Zvulun Elazar: Department of Biomolecular Sciences, The Weizmann Institute of Science

DOI: https://doi.org/10.1038/s41467-018-06275-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The TNF receptor Fn14 is a short-lived protein. Here the authors show that Fn14 turnover is regulated by selective autophagy, with different ATG8 proteins having distinct roles during the process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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