Nature Communications (Nov 2016)
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
- Piero Dalle Pezze,
- Stefanie Ruf,
- Annika G. Sonntag,
- Miriam Langelaar-Makkinje,
- Philip Hall,
- Alexander M. Heberle,
- Patricia Razquin Navas,
- Karen van Eunen,
- Regine C. Tölle,
- Jennifer J. Schwarz,
- Heike Wiese,
- Bettina Warscheid,
- Jana Deitersen,
- Björn Stork,
- Erik Fäßler,
- Sascha Schäuble,
- Udo Hahn,
- Peter Horvatovich,
- Daryl P. Shanley,
- Kathrin Thedieck
Affiliations
- Piero Dalle Pezze
- Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University
- Stefanie Ruf
- Department of Bioinformatics and Molecular Genetics (Faculty of Biology), Institute for Biology 3, Albert-Ludwigs-University Freiburg
- Annika G. Sonntag
- Department of Bioinformatics and Molecular Genetics (Faculty of Biology), Institute for Biology 3, Albert-Ludwigs-University Freiburg
- Miriam Langelaar-Makkinje
- Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG)
- Philip Hall
- Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University
- Alexander M. Heberle
- Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG)
- Patricia Razquin Navas
- Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG)
- Karen van Eunen
- Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG)
- Regine C. Tölle
- Department of Bioinformatics and Molecular Genetics (Faculty of Biology), Institute for Biology 3, Albert-Ludwigs-University Freiburg
- Jennifer J. Schwarz
- Department of Bioinformatics and Molecular Genetics (Faculty of Biology), Institute for Biology 3, Albert-Ludwigs-University Freiburg
- Heike Wiese
- Department of Biochemistry and Functional Proteomics, Faculty of Biology, University of Freiburg
- Bettina Warscheid
- Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg
- Jana Deitersen
- Institute of Molecular Medicine I, Medical Faculty, Heinrich-Heine-University
- Björn Stork
- Institute of Molecular Medicine I, Medical Faculty, Heinrich-Heine-University
- Erik Fäßler
- Jena University Language & Information Engineering (JULIE) Lab, Friedrich-Schiller-University Jena
- Sascha Schäuble
- Jena University Language & Information Engineering (JULIE) Lab, Friedrich-Schiller-University Jena
- Udo Hahn
- Jena University Language & Information Engineering (JULIE) Lab, Friedrich-Schiller-University Jena
- Peter Horvatovich
- Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Analytical Biochemistry, University of Groningen
- Daryl P. Shanley
- Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University
- Kathrin Thedieck
- Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG)
- DOI
- https://doi.org/10.1038/ncomms13254
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 19
Abstract
mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions.
