Comptes Rendus. Chimie (Feb 2022)
Pathologies related to abnormal deposits in dermatology: a physico-chemical approach
- Colboc, Hester,
- Moguelet, Philippe,
- Letavernier, Emmanuel,
- Frochot, Vincent,
- Bernaudin, Jean-François,
- Weil, Raphaël,
- Rouzière, Stéphan,
- Senet, Patricia,
- Bachmeyer, Claude,
- Laporte, Naomi,
- Lucas, Ivan,
- Descamps, Vincent,
- Amode, Reyhan,
- Brunet-Possenti, Florence,
- Kluger, Nicolas,
- Deschamps, Lydia,
- Dubois, Arnaud,
- Reguer, Solenn,
- Somogyi, Andrea,
- Medjoubi, Kadda,
- Refregiers, Matthieu,
- Daudon, Michel,
- Bazin, Dominique
Affiliations
- Colboc, Hester
- ORCiD
- Sorbonne Université, AP-HP, Hôpital Rothschild, Service Plaies et Cicatrisation, Paris, France
- Moguelet, Philippe
- ORCiD
- Sorbonne Université, AP-HP, Hôpital Tenon, Anatomie et Cytologie Pathologiques, Paris, France
- Letavernier, Emmanuel
- ORCiD
- Sorbonne Université, AP-HP, Hôpital Tenon, Service d’explorations fonctionnelles, Paris, France; INSERM, UMRS 1155, Sorbonne Université, Hôpital Tenon, Paris, France
- Frochot, Vincent
- Sorbonne Université, AP-HP, Hôpital Tenon, Service d’explorations fonctionnelles, Paris, France; INSERM, UMRS 1155, Sorbonne Université, Hôpital Tenon, Paris, France
- Bernaudin, Jean-François
- Faculté de médecine Sorbonne Université, Paris, France; INSERM UMR 1272 Université Sorbonne Paris-Nord, Bobigny, France
- Weil, Raphaël
- ORCiD
- Université Paris-Saclay, CNRS, Laboratoire de Physique des Solides, 91405, Orsay, France
- Rouzière, Stéphan
- ORCiD
- Université Paris-Saclay, CNRS, Laboratoire de Physique des Solides, 91405, Orsay, France
- Senet, Patricia
- Sorbonne Université, AP-HP, Hôpital Tenon, Service de Dermatologie, Paris, France
- Bachmeyer, Claude
- ORCiD
- Sorbonne Université, AP-HP, Hôpital Tenon, Service de Médecine Interne, Paris, France
- Laporte, Naomi
- Sorbonne Université, AP-HP, Hôpital Rothschild, Service Plaies et Cicatrisation, Paris, France
- Lucas, Ivan
- Sorbonne Université, UMR 8235, Paris, France
- Descamps, Vincent
- ORCiD
- Service de Dermatologie, AP-HP, Hôpital Bichat, Paris, France
- Amode, Reyhan
- ORCiD
- Service de Dermatologie, AP-HP, Hôpital Bichat, Paris, France
- Brunet-Possenti, Florence
- ORCiD
- Service de Dermatologie, AP-HP, Hôpital Bichat, Paris, France
- Kluger, Nicolas
- ORCiD
- Service de Dermatologie, AP-HP, Hôpital Bichat, Paris, France; Department of Dermatology, Allergology and Venereology, Helsinki University Hospital, Helsinki, Finland
- Deschamps, Lydia
- ORCiD
- Anatomie et Cytologie Pathologiques, AP-HP, Hôpital Bichat, Paris, France
- Dubois, Arnaud
- ORCiD
- Laboratoire Charles Fabry, CNRS, Institut d’Optique Graduate School, Université Paris-Saclay, Palaiseau, France
- Reguer, Solenn
- ORCiD
- Synchrotron SOLEIL L’Orme des Merisiers Saint-Aubin, Synchrotron Soleil, Gif-sur-Yvette, France
- Somogyi, Andrea
- ORCiD
- Synchrotron SOLEIL L’Orme des Merisiers Saint-Aubin, Synchrotron Soleil, Gif-sur-Yvette, France
- Medjoubi, Kadda
- ORCiD
- Synchrotron SOLEIL L’Orme des Merisiers Saint-Aubin, Synchrotron Soleil, Gif-sur-Yvette, France
- Refregiers, Matthieu
- ORCiD
- Synchrotron SOLEIL L’Orme des Merisiers Saint-Aubin, Synchrotron Soleil, Gif-sur-Yvette, France
- Daudon, Michel
- ORCiD
- Sorbonne Université, AP-HP, Hôpital Tenon, Service d’explorations fonctionnelles, Paris, France; INSERM, UMRS 1155, Sorbonne Université, Hôpital Tenon, Paris, France
- Bazin, Dominique
- ORCiD
- Université Paris-Saclay, CNRS, Institut de Chimie Physique, 91405, Orsay, France
- DOI
- https://doi.org/10.5802/crchim.153
- Journal volume & issue
-
Vol. 25,
no. S1
pp. 445 – 476
Abstract
Although numerous pathologies are associated with abnormal skin deposits, these remain poorly described, as accurate characterization continues to present a challenge for dermatologists. Their submicrometer size as well as their diverse chemistry require various characterization tools. We aim to exemplify characterization of endogenous and exogenous skin deposits in some selected skin diseases using different physico-chemical techniques. We begin with a presentation of selected diseases associated with skin deposits. We then present those of our results which show their variety of structure, location and chemical composition, obtained with various tools: Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy, X-ray fluorescence, vibrational spectroscopies, as well as techniques specific to synchrotron radiation. Our results constitute a real opportunity to improve diagnosis, and to understand the pathogenesis of many skin diseases, and opportunities for therapeutic intervention.
Keywords
