Leukocyte mitochondrial DNA copy number and cardiovascular disease: A systematic review and meta-analysis of cohort studies

Xinying Li; Xiaoning Liu; Xiaojuan Chen; Yanqi Wang; Shuning Wu; Fengjuan Li; Yuhao Su; Lifang Chen; Jian Xiao; Jianping Ma; Pei Qin

iScience (Sep 2024)

Leukocyte mitochondrial DNA copy number and cardiovascular disease: A systematic review and meta-analysis of cohort studies

Xinying Li,
Xiaoning Liu,
Xiaojuan Chen,
Yanqi Wang,
Shuning Wu,
Fengjuan Li,
Yuhao Su,
Lifang Chen,
Jian Xiao,
Jianping Ma,
Pei Qin

Affiliations

Xinying Li: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China; School of Public Health, Shantou University, Shantou, Guangdong, China
Xiaoning Liu: Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Xiaojuan Chen: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China; School of Public Health, Shantou University, Shantou, Guangdong, China
Yanqi Wang: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China; School of Public Health, Shantou University, Shantou, Guangdong, China
Shuning Wu: Department of Thyroid and Breast Surgery, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China
Fengjuan Li: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China; School of Public Health, Shantou University, Shantou, Guangdong, China
Yuhao Su: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China; School of Public Health, Shantou University, Shantou, Guangdong, China
Lifang Chen: Department of Cardiovascular Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518000, Guangdong, China
Jian Xiao: Department of Cardiovascular Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518000, Guangdong, China
Jianping Ma: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China
Pei Qin: Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China; Corresponding author

Journal volume & issue: Vol. 27, no. 9
p. 110522

Abstract

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Summary: Increasing cohort studies have examined the link between mitochondrial DNA copy number (mtDNA-CN) and cardiovascular disease (CVD), with inconsistent findings. We searched PubMed, EMBASE, and Web of Science up to July 11, 2023 and used a random-effects model to calculate summary hazard ratios (HRs) and 95% confidence intervals (CIs). This systematic review and meta-analysis included 8 articles encompassing 29 studies with 646,398 participants. Individuals with the lowest mtDNA-CN had a summary HR of 1.27 (95% CI 1.02–1.59) for CVD, 1.18 (95% CI 0.92–1.50) for coronary heart disease (CHD), 1.10 (95% CI 0.89–1.37) for stroke, and 1.30 (95% CI 1.07–1.56) for heart failure (HF). Decreased mtDNA-CN is linked to an increased risk of CVD and HF but not CHD and stroke. These findings suggest mtDNA-CN from leukocytes may be a potential early biomarker for CVD. However, more prospective studies with long follow-up are needed.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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