Effectiveness of Gum Arabic With and Without Insulin on the Relieve of Some metabolic Complications of Diabetes Mellitus in Sprague-Dawley Rats

Abstract

Background: This article aims to investigate the effect of gum Arabic dose with or without insulin on the expression of antioxidant and liver enzymes and the concentration of malondialdehyde (MDA), reduced glutathione (GSH), direct bilirubin, total bilirubin, albumin, and total proteins. Materials and Methods: This study was composed of five groups, Group 0 as control group (injected citrate buffer only), Group 1 was diabetic (treated with streptozocin), Group 2 was diabetic and treated with insulin, Group 3 was diabetic treated with gum Arabic, and Group 4 was diabetic treated with gum Arabic and insulin. However, each group involved 10 Sprague-Dawley rats. The ELISA techniques were used to determine the concentration of the oxidative stress parameters. The liver function test’s parameters were measured by a spectrophotometer. Results: The gum Arabic is an effective antioxidant factor, but it has some negative effects on the liver function test parameters. Conclusion: The combined or dual dose of insulin and gum Arabic is better than the insulin or gum Arabic alone as an antioxidant factor for the treatment of diabetic rats.

Keywords

• diabetic sprague-dawley rats
• gum arabic
• insulin
• liver function
• oxidative stress.