Nature Communications (Nov 2016)

Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

  • Chen Xu,
  • Yan Zhang,
  • Qiaoling Wang,
  • Zhenyu Xu,
  • Junfeng Jiang,
  • Yuping Gao,
  • Minzhi Gao,
  • Jiuhong Kang,
  • Minjuan Wu,
  • Jun Xiong,
  • Kaihong Ji,
  • Wen Yuan,
  • Yue Wang,
  • Houqi Liu

DOI
https://doi.org/10.1038/ncomms13287
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 18

Abstract

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Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.