Loss of CDC4/FBXW7 in Gastric Carinoma

A. N. Milne; R. Leguit; W. E. Corver; F. H. M. Morsink; M. Polak; W. W. de Leng; R. Carvalho; G. J. A. Offerhaus

doi:10.3233/CLO-2010-523

Cellular Oncology (Jan 2010)

Loss of CDC4/FBXW7 in Gastric Carinoma

A. N. Milne,
R. Leguit,
W. E. Corver,
F. H. M. Morsink,
M. Polak,
W. W. de Leng,
R. Carvalho,
G. J. A. Offerhaus

Affiliations

A. N. Milne: Department of Pathology, University Medical Centre, Utrecht, The Netherlands
R. Leguit: Department of Pathology, University Medical Centre, Utrecht, The Netherlands
W. E. Corver: Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
F. H. M. Morsink: Department of Pathology, University Medical Centre, Utrecht, The Netherlands
M. Polak: Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands
W. W. de Leng: Department of Pathology, University Medical Centre, Utrecht, The Netherlands
R. Carvalho: ZF-Screens BV, Leiden, The Netherlands
G. J. A. Offerhaus: Department of Pathology, University Medical Centre, Utrecht, The Netherlands

DOI: https://doi.org/10.3233/CLO-2010-523
Journal volume & issue: Vol. 32, no. 5-6
pp. 347 – 359

Abstract

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Background: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor suppressor gene and therapeutic target in many tumor types. Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in gastric carcinogenesis.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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