Detection of potential effects of orphenadrine upon anesthesia with propofol and/or thiopental in mice

Abstract

Orphenadrine is an anticholinergic drug used in clinics as a muscle relaxant. It acts on several receptors, including muscarinic, histaminic, and NMDA. This study aimed to evaluate the effect of pretreatment with orphenadrine on the anesthesia indices of two essential parenteral anesthetic drugs in mice. Three experiments were performed with 15 mice per experiment. All experiments used orphenadrine at 10 mg and 20 mg/kg/IP b.wt as a pretreatment drug. Propofol (100 mg/kg/IP), thiopental (50 mg/kg/IP), and their combinations were used in the first, second, and third experiments, respectively. The indices of anesthesia, represented by the latency to onset of anesthesia, duration of anesthesia, and recovery from anesthesia, were recorded. Orphenadrine at doses of 10 mg and 20 mg/kg/IP as a pretreatment drug showed a dose-dependent decrease in the latency to the onset of anesthesia and an increase in the duration of anesthesia compared to the control groups of all three experiments (propofol 100 mg/kg, thiopental 50 mg/kg, and combinations of propofol and thiopental) respectively. We conclude that orphenadrine affects anesthesia indices, which are recorded for the first time, laying the foundation for further studies and the possibility of using it as an anesthesia co-treatment.

Keywords

• orphenadrine
• propofol
• thiopental
• anesthesia indices
• mice