Nature Communications (May 2018)
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
- Evelien M. Bunnik,
- Kate B. Cook,
- Nelle Varoquaux,
- Gayani Batugedara,
- Jacques Prudhomme,
- Anthony Cort,
- Lirong Shi,
- Chiara Andolina,
- Leila S. Ross,
- Declan Brady,
- David A. Fidock,
- Francois Nosten,
- Rita Tewari,
- Photini Sinnis,
- Ferhat Ay,
- Jean-Philippe Vert,
- William Stafford Noble,
- Karine G. Le Roch
Affiliations
- Evelien M. Bunnik
- Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Health Science Center at San Antonio
- Kate B. Cook
- Department of Genome Sciences, University of Washington
- Nelle Varoquaux
- Department of Statistics, University of California
- Gayani Batugedara
- Department of Molecular, Cell and Systems Biology, University of California Riverside
- Jacques Prudhomme
- Department of Molecular, Cell and Systems Biology, University of California Riverside
- Anthony Cort
- Department of Molecular, Cell and Systems Biology, University of California Riverside
- Lirong Shi
- Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
- Chiara Andolina
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research building, University of Oxford, Old Road campus
- Leila S. Ross
- Department of Microbiology and Immunology, Columbia University Medical Center
- Declan Brady
- School of Life Sciences, Queens Medical Centre, University of Nottingham
- David A. Fidock
- Department of Microbiology and Immunology, Columbia University Medical Center
- Francois Nosten
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine Research building, University of Oxford, Old Road campus
- Rita Tewari
- School of Life Sciences, Queens Medical Centre, University of Nottingham
- Photini Sinnis
- Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
- Ferhat Ay
- La Jolla Institute for Allergy & Immunology
- Jean-Philippe Vert
- MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology
- William Stafford Noble
- Department of Genome Sciences, University of Washington
- Karine G. Le Roch
- Department of Molecular, Cell and Systems Biology, University of California Riverside
- DOI
- https://doi.org/10.1038/s41467-018-04295-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The development of malaria parasites is controlled by coordinated changes in gene expression. Here, the authors show that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycles of Plasmodium falciparum and Plasmodium vivax parasites.
