The serum immunoglobulin G glycosylation signature of gastric cancer

L. Renee Ruhaak; Donald A. Barkauskas; Javier Torres; Cara L. Cooke; Lauren D. Wu; Carol Stroble; Sureyya Ozcan; Cynthia C. Williams; Margarita Camorlinga; David M. Rocke; Carlito B. Lebrilla; Jay V. Solnick

doi:10.1016/j.euprot.2014.11.002

EuPA Open Proteomics (Mar 2015)

The serum immunoglobulin G glycosylation signature of gastric cancer

L. Renee Ruhaak,
Donald A. Barkauskas,
Javier Torres,
Cara L. Cooke,
Lauren D. Wu,
Carol Stroble,
Sureyya Ozcan,
Cynthia C. Williams,
Margarita Camorlinga,
David M. Rocke,
Carlito B. Lebrilla,
Jay V. Solnick

Affiliations

L. Renee Ruhaak: Department of Chemistry, University of California, Davis, CA 95616, USA
Donald A. Barkauskas: Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
Javier Torres: Infectious Diseases Research Unit, Instituto Mexicano del Seguro Social, Mexico
Cara L. Cooke: Department of Medicine, Center for Comparative Medicine, University of California, Davis School of Medicine, Davis, CA 95616, USA
Lauren D. Wu: Department of Chemistry, University of California, Davis, CA 95616, USA
Carol Stroble: Department of Chemistry, University of California, Davis, CA 95616, USA
Sureyya Ozcan: Department of Chemistry, University of California, Davis, CA 95616, USA
Cynthia C. Williams: Department of Chemistry, University of California, Davis, CA 95616, USA
Margarita Camorlinga: Infectious Diseases Research Unit, Instituto Mexicano del Seguro Social, Mexico
David M. Rocke: Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
Carlito B. Lebrilla: Department of Chemistry, University of California, Davis, CA 95616, USA
Jay V. Solnick: Department of Medicine, Center for Comparative Medicine, University of California, Davis School of Medicine, Davis, CA 95616, USA

DOI: https://doi.org/10.1016/j.euprot.2014.11.002
Journal volume & issue: Vol. 6, no. C
pp. 1 – 9

Abstract

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Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC–TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly between NAG and GC, three that distinguished NAG from DU, and eight that differed between DU and GC. The IgG glycosylation signature may be useful as a predictive marker for gastric cancer.

Published in EuPA Open Proteomics

ISSN: 2212-9685 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General): Genetics
Website: http://www.journals.elsevier.com/eupa-open-proteomics/

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