Nature Communications (Oct 2018)
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
- Lucrezia Colonna,
- Christopher W. Peterson,
- John B. Schell,
- Judith M. Carlson,
- Victor Tkachev,
- Melanie Brown,
- Alison Yu,
- Sowmya Reddy,
- Willi M. Obenza,
- Veronica Nelson,
- Patricia S. Polacino,
- Heather Mack,
- Shiu-Lok Hu,
- Katie Zeleski,
- Michelle Hoffman,
- Joe Olvera,
- Scott N. Furlan,
- Hengqi Zheng,
- Agne Taraseviciute,
- Daniel J. Hunt,
- Kayla Betz,
- Jennifer F. Lane,
- Keith Vogel,
- Charlotte E. Hotchkiss,
- Cassie Moats,
- Audrey Baldessari,
- Robert D. Murnane,
- Christopher English,
- Cliff A. Astley,
- Solomon Wangari,
- Brian Agricola,
- Joel Ahrens,
- Naoto Iwayama,
- Andrew May,
- Laurence Stensland,
- Meei-Li W. Huang,
- Keith R. Jerome,
- Hans-Peter Kiem,
- Leslie S. Kean
Affiliations
- Lucrezia Colonna
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Christopher W. Peterson
- Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N
- John B. Schell
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Judith M. Carlson
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Victor Tkachev
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Melanie Brown
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Alison Yu
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Sowmya Reddy
- Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N
- Willi M. Obenza
- Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N
- Veronica Nelson
- Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N
- Patricia S. Polacino
- Washington National Primate Research Center
- Heather Mack
- Washington National Primate Research Center
- Shiu-Lok Hu
- Washington National Primate Research Center
- Katie Zeleski
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Michelle Hoffman
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Joe Olvera
- Washington National Primate Research Center
- Scott N. Furlan
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Hengqi Zheng
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Agne Taraseviciute
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Daniel J. Hunt
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Kayla Betz
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- Jennifer F. Lane
- Washington National Primate Research Center
- Keith Vogel
- Washington National Primate Research Center
- Charlotte E. Hotchkiss
- Washington National Primate Research Center
- Cassie Moats
- Washington National Primate Research Center
- Audrey Baldessari
- Washington National Primate Research Center
- Robert D. Murnane
- Washington National Primate Research Center
- Christopher English
- Washington National Primate Research Center
- Cliff A. Astley
- Washington National Primate Research Center
- Solomon Wangari
- Washington National Primate Research Center
- Brian Agricola
- Washington National Primate Research Center
- Joel Ahrens
- Washington National Primate Research Center
- Naoto Iwayama
- Washington National Primate Research Center
- Andrew May
- Washington National Primate Research Center
- Laurence Stensland
- Department of Laboratory Medicine, University of Washington
- Meei-Li W. Huang
- Department of Laboratory Medicine, University of Washington
- Keith R. Jerome
- Department of Laboratory Medicine, University of Washington
- Hans-Peter Kiem
- Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N
- Leslie S. Kean
- Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-06736-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation.
