Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults

Isabel J. Sible; Belinda Yew; Shubir Dutt; Yanrong Li; Anna E. Blanken; Jung Yun Jang; Jean K. Ho; Anisa J. Marshall; Arunima Kapoor; Aimée Gaubert; Katherine J. Bangen; Virginia E. Sturm; Xingfeng Shao; Danny J. Wang; Daniel A. Nation

Neuroimage: Reports (Mar 2022)

Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults

Isabel J. Sible,
Belinda Yew,
Shubir Dutt,
Yanrong Li,
Anna E. Blanken,
Jung Yun Jang,
Jean K. Ho,
Anisa J. Marshall,
Arunima Kapoor,
Aimée Gaubert,
Katherine J. Bangen,
Virginia E. Sturm,
Xingfeng Shao,
Danny J. Wang,
Daniel A. Nation

Affiliations

Isabel J. Sible: Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA
Belinda Yew: Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA
Shubir Dutt: Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA
Yanrong Li: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA
Anna E. Blanken: Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA
Jung Yun Jang: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA
Jean K. Ho: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA
Anisa J. Marshall: Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA
Arunima Kapoor: Department of Psychological Science, University of California Irvine, Irvine, CA, 92697, USA
Aimée Gaubert: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA
Katherine J. Bangen: Research Service, Veteran Affairs San Diego Healthcare System, San Diego, CA, 92161, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, 92093, USA
Virginia E. Sturm: Department of Neurology, University of California, San Francisco, CA, 94158, USA; Department of Psychiatry, University of California, San Francisco, CA, 94158, USA; Global Brain Health Institute, University of California, San Francisco, CA, 94158, USA
Xingfeng Shao: Laboratory of Functional MRI Technology, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA
Danny J. Wang: Laboratory of Functional MRI Technology, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA
Daniel A. Nation: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA; Department of Psychological Science, University of California Irvine, Irvine, CA, 92697, USA; Corresponding author. University of California Irvine Department of Psychological Science 4201 Social and Behavioral Sciences Gateway Irvine, CA, USA

Journal volume & issue: Vol. 2, no. 1
p. 100080

Abstract

Read online

Blood pressure variability is an emerging risk factor for stroke, cognitive impairment, and dementia, possibly through links with cerebral hypoperfusion. Recent evidence suggests visit-to-visit (e.g., over months, years) blood pressure variability is related to cerebral perfusion decline in brain regions vulnerable to Alzheimer's disease. However, less is known about relationships between short-term (e.g., <24 h) blood pressure variability and regional cerebral perfusion, and whether these relationships may differ by age. We investigated short-term blood pressure variability and concurrent regional cerebral microvascular perfusion in a sample of community-dwelling older adults without history of dementia or stroke and healthy younger adults. Blood pressure was collected continuously during perfusion MRI. Cerebral blood flow was determined for several brain regions implicated in cerebrovascular dysfunction in Alzheimer's disease. Elevated systolic blood pressure variability was related to lower levels of concurrent cerebral perfusion in medial temporal regions: hippocampus (ß = −0.60 [95% CI -0.90, −0.30]; p < .001), parahippocampal gyrus (ß = −0.57 [95% CI -0.89, −0.25]; p = .001), entorhinal cortex (ß = −0.42 [95% CI -0.73, −0.12]; p = .009), and perirhinal cortex (ß = −0.37 [95% CI -0.72, −0.03]; p = .04), and not in other regions, and in older adults only. Findings suggest a possible age-related selective vulnerability of the medial temporal lobes to hypoperfusion in the context of short-term blood pressure fluctuations, independent of average blood pressure, white matter hyperintensities, and gray matter volume, which may underpin the increased risk for dementia associated with elevated BPV.1

Published in Neuroimage: Reports

ISSN: 2666-9560 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage-reports

About the journal

Abstract

Keywords