African Swine Fever Virus F317L Protein Inhibits NF-κB Activation To Evade Host Immune Response and Promote Viral Replication

Jinping Yang; Shasha Li; Tao Feng; Xiangle Zhang; Fan Yang; Weijun Cao; Hongjun Chen; Huisheng Liu; Keshan Zhang; Zixiang Zhu; Haixue Zheng

doi:10.1128/mSphere.00658-21

mSphere (Oct 2021)

African Swine Fever Virus F317L Protein Inhibits NF-κB Activation To Evade Host Immune Response and Promote Viral Replication

Jinping Yang,
Shasha Li,
Tao Feng,
Xiangle Zhang,
Fan Yang,
Weijun Cao,
Hongjun Chen,
Huisheng Liu,
Keshan Zhang,
Zixiang Zhu,
Haixue Zheng

Affiliations

Jinping Yang: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Shasha Li: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Tao Feng: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Xiangle Zhang: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Fan Yang: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Weijun Cao: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Hongjun Chen: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
Huisheng Liu: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Keshan Zhang: ORCiD; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
Zixiang Zhu: ORCiD; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China
Haixue Zheng: ORCiD; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

DOI: https://doi.org/10.1128/mSphere.00658-21
Journal volume & issue: Vol. 6, no. 5

Abstract

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African swine fever (ASF) is one of the most important pig diseases, causing a high case fatality rate and trade restrictions upon reported outbreaks. The limited understanding of the functions of the proteins of the causative agent, African swine fever virus (ASFV), has become a primary barrier to developing available commercial ASFV vaccines.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal