Domperidone loaded Caesalpinia pulcherrima galactomannan-based microspheres for nasal administration: In-vitro and In-vivo studies

Abstract

Caesalpinia pulcherrima galactomannan (CPG) based Domperidone (DOM) spray-dried mucoadhesive microspheres for nasal administration were developed using 23 FD to avoid first-pass metabolism, with improved therapeutic efficiency for treatment of nausea and vomiting as an alternative therapy to parenterals. Concentration of polymer, inlet temperature, and aspirator speed were selected for manipulated independent variables, whereas %entrapment efficiency and %drug release were the dependent variables. The developed microspheres were evaluated for particle size, entrapment efficiency, zeta potential, swelling ability, in-vitro mucoadhesion, in-vitro drug release, and DSC and XRD responses. The developed formulation was studied in rabbit for screening nasal absorption potential. The formulation possesses in vitro drug release from 62.87% to 94.80%, entrapment efficiency from 89.69% to 98.64%, and mucoadhesion from 73.6 to 82.47% across goat nasal mucosa. In vivo study in rabbit showed that DOM microspheres provide quick drug absorption, and enhanced bioavailability of drug upon nasal administration as compared to oral route. Thus, the developed DOM based formulation can be alternative to oral and parenteral formulations.

Keywords

• domperidone
• caesalpinia pulcherrima galactomannan
• mucoadhesive microspheres
• ndds
• spray drying