International Journal of General Medicine (Dec 2021)
Predictors of COVID-19 Hospital Treatment Outcome
Abstract
Ryszard Tomasiuk,1 Jan Dabrowski,2 Jolanta Smykiewicz,3 Magdalena Wiacek4 1Department of Medicine, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, Poland; 2Department of Pharmacology, National Medicines Institute, Warsaw, Poland; 3Central Medical Diagnostic Laboratory, Dr. Tytus Chałubiński Specialist Hospital in Radom, Radom, Poland; 4Department of Physiotherapy, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, PolandCorrespondence: Ryszard TomasiukDepartment of Medicine, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, PolandEmail [email protected]: There are more than 228,394,572 confirmed cases and 4,690,186 confirmed deaths caused by COVID-19 worldwide. The magnitude of the COOVID-19 pandemic has stimulated research on the treatment and diagnosis of COVID-19 patients.Objective: In this report, a battery of specific parameters was used to develop a model that allows prediction of the outcome of the COVID-19 treatment. These parameters are C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6.Methods: The study was carried out on a sample of N = 49 survivors (22 men, 27 women) and 83 deceased patients (62 men, 21 women). The distribution of means and differences in means of the parameters studied between survivors and deceased patients were evaluated using the bootstrap method.Results: A mathematical model that allows for the prediction of hospitalization outcome was obtained using the Naive Bayes model. The results demonstrated a statistically significant difference between survivors and deceased patients in all parameters studied. A mathematical model employing a battery of parameters provided a 97% precision in predicting the outcome of hospitalization.Conclusion: This study showed that the cross-correlation of survivability with absolute levels of C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6 could be used successfully in the hospital setting as a diagnostic tool.Keywords: Covid-19, biological markers, C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, interleukin-6
