Nature Communications (Nov 2019)
Genomic and immune profiling of pre-invasive lung adenocarcinoma
- Haiquan Chen,
- Jian Carrot-Zhang,
- Yue Zhao,
- Haichuan Hu,
- Samuel S. Freeman,
- Su Yu,
- Gavin Ha,
- Alison M. Taylor,
- Ashton C. Berger,
- Lindsay Westlake,
- Yuanting Zheng,
- Jiyang Zhang,
- Aruna Ramachandran,
- Qiang Zheng,
- Yunjian Pan,
- Difan Zheng,
- Shanbo Zheng,
- Chao Cheng,
- Muyu Kuang,
- Xiaoyan Zhou,
- Yang Zhang,
- Hang Li,
- Ting Ye,
- Yuan Ma,
- Zhendong Gao,
- Xiaoting Tao,
- Han Han,
- Jun Shang,
- Ying Yu,
- Ding Bao,
- Yechao Huang,
- Xiangnan Li,
- Yawei Zhang,
- Jiaqing Xiang,
- Yihua Sun,
- Yuan Li,
- Andrew D. Cherniack,
- Joshua D. Campbell,
- Leming Shi,
- Matthew Meyerson
Affiliations
- Haiquan Chen
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Jian Carrot-Zhang
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Yue Zhao
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Haichuan Hu
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Samuel S. Freeman
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Su Yu
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Gavin Ha
- Computational Biology Program, Fred Hutchinson Cancer Research Center
- Alison M. Taylor
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Ashton C. Berger
- Broad Institute of MIT and Harvard
- Lindsay Westlake
- Broad Institute of MIT and Harvard
- Yuanting Zheng
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Jiyang Zhang
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Aruna Ramachandran
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Qiang Zheng
- Department of Oncology, Shanghai Medical College, Fudan University
- Yunjian Pan
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Difan Zheng
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Shanbo Zheng
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Chao Cheng
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Muyu Kuang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Xiaoyan Zhou
- Department of Oncology, Shanghai Medical College, Fudan University
- Yang Zhang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Hang Li
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Ting Ye
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Yuan Ma
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Zhendong Gao
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Xiaoting Tao
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Han Han
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Jun Shang
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Ying Yu
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Ding Bao
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Yechao Huang
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Xiangnan Li
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Yawei Zhang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Jiaqing Xiang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Yihua Sun
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Yuan Li
- Department of Oncology, Shanghai Medical College, Fudan University
- Andrew D. Cherniack
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Joshua D. Campbell
- Division of Computational Biomedicine, Department of Medicine, Boston University
- Leming Shi
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Matthew Meyerson
- Department of Medical Oncology, Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-019-13460-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 6
Abstract
The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.
