Chloroquine-Based Mitochondrial ATP Inhibitors

Zhiguo Wang; Robert J. Sheaff; Syed R. Hussaini

doi:10.3390/molecules28031161

Molecules (Jan 2023)

Chloroquine-Based Mitochondrial ATP Inhibitors

Zhiguo Wang,
Robert J. Sheaff,
Syed R. Hussaini

Affiliations

Zhiguo Wang: Department of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA
Robert J. Sheaff: Department of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA
Syed R. Hussaini: Department of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA

DOI: https://doi.org/10.3390/molecules28031161
Journal volume & issue: Vol. 28, no. 3
p. 1161

Abstract

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Mitochondria is an important drug target for ailments ranging from neoplastic to neurodegenerative diseases and metabolic diseases. Here, we describe the synthesis of chloroquine analogs and show the results of mitochondrial ATP inhibition testing. The 2,4-dinitrobenzene-based analogs showed concentration-dependent mitochondrial (mito.) ATP inhibition. The most potent mito. ATP inhibitor was found to be N-(4-((2,4-Dinitrophenyl)amino)pentyl)-N-ethylacetamide (17).

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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