Research progress of NT5C2 in disease and treatment

SHU Ling, HUO Bennian, SONG Lin

doi:10.16352/j.issn.1001-6325.2023.05.0852

Jichu yixue yu linchuang (May 2023)

Research progress of NT5C2 in disease and treatment

SHU Ling, HUO Bennian, SONG Lin

Affiliations

SHU Ling, HUO Bennian, SONG Lin: Department of Pharmacy, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China

DOI: https://doi.org/10.16352/j.issn.1001-6325.2023.05.0852
Journal volume & issue: Vol. 43, no. 5
pp. 852 – 856

Abstract

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Cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), the protein encoded by NT5C2, can catalyze the dephosphory-lation of nucleoside monophosphate and is mainly involved in the regulation of purine nucleotide pool in cells. High expression of cN-Ⅱ mRNA is associated with poor prognosis of patients with acute leukemia (AL). Acquired NT5C2 mutation will hinder the formation of DNA and thioguanine nucleotide (TGN) conjugate, resulting in 6-mercaptpurine(6-MP) resistance. In addition, NT5C2 is a risk factor associated with type Ⅱ diabetes, schizophrenia and other diseases.

nt5c2|cytosolic 5'-nucleotidase ⅱ(cn-ⅱ)|nucleoside analogue|acute leukemia(al)|type 2 diabetes

Published in Jichu yixue yu linchuang

ISSN: 1001-6325 (Print)
Publisher: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Country of publisher: China
LCC subjects: Medicine
Website: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/1001-6325/home.shtml

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Abstract

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