Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

mBio (Feb 2021)

Affiliations

Malligarjunan Rajavel: Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
Vijay Kumar: ORCiD; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
Ha Nguyen: Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
Jacob Wyatt: Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
Steven H. Marshall: Louis Stokes Cleveland Veteran’s Affairs Medical Center Research Service, Cleveland, Ohio, USA
Krisztina M. Papp-Wallace: ORCiD; Louis Stokes Cleveland Veteran’s Affairs Medical Center Research Service, Cleveland, Ohio, USA
Prasad Deshpande: Wockhardt Research Centre, Aurangabad, India
Satish Bhavsar: Wockhardt Research Centre, Aurangabad, India
Ravindra Yeole: Wockhardt Research Centre, Aurangabad, India
Sachin Bhagwat: Wockhardt Research Centre, Aurangabad, India
Mahesh Patel: Wockhardt Research Centre, Aurangabad, India
Robert A. Bonomo: ORCiD; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
Focco van den Akker: ORCiD; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.