P1.10 PULSE PRESSURE IN RELATION TO 24-HOUR URINARY SODIUM EXCRETION IN A SAMPLE OF HIGH-SALT INTAKE POPULATION

Abstract

Objectives: In recent years, many studies emphasized the role of arterial rigidity in the development of cardiovascular diseases. Pulse pressure in an easy-obtained, reproducible marker of arterial stiffness and an independent cardiovascular risk factor. On the other hand it was observed that sodium restriction could improve large elastic artery compliance. The aim of the study was to investigate the relation between salt intake and pulse pressure in high salt intake population. Methods: The study group included 303 subjects recruited from the general population of Southern Poland. Ambulatory blood pressure (ABP) monitors (SpaceLabs 90207) were programmed to obtain measurements each 15 min. during the day and each 30 min. nighttime. Based on the ABP data, we calculated pulse pressure (PP) over 24h, daytime and nighttime. Sodium intake was assessed based on 24h urinary sodium excretion. Database management and statistical analysis were performed with SAS software. Results: The study group included 136 men and 167 women, with 165 hypertensive individuals, 105 of them on antihypertensive treatment, mean age = 47.1 ± 15.7 yrs. While adjusting for age, sex, body mass index, 24h blood pressure, antihypertensive treatment, and life style, we observed positive relation between sodium intake and 24h PP ([beta±SE]: 0.016 ± 0.006, p = 0.0075), daytime PP ([beta±SE]: 0.011 ± 0.005, p = 0.029) and non-significant trend regarding nighttime PP ([beta±SE]: 0.009 ± 0.005, p = 0.094). Conclusion: In our high salt intake population, sodium intake was positively related to calculated pulse pressure over 24-hour and daytime.