Telitacicept Treatment Refractory Lupus Nephritis: A Case Report

Sijia Li; Shuting Deng; Sichun Wen; Siqi Peng; Nan Jiang; Bohou Li; Boxi Chen; Ye Yuan; Qiong Wu; Yiming Tao; Jianchao Ma; Ting Lin; Feng Wen; Zhuo Li; Hao Dai; Renwei Huang; Zhonglin Feng; Zhilian Li; Shuangxin Liu; Lixia Xu

doi:10.1159/000538033

Case Reports in Nephrology and Dialysis (Mar 2024)

Telitacicept Treatment Refractory Lupus Nephritis: A Case Report

Sijia Li,
Shuting Deng,
Sichun Wen,
Siqi Peng,
Nan Jiang,
Bohou Li,
Boxi Chen,
Ye Yuan,
Qiong Wu,
Yiming Tao,
Jianchao Ma,
Ting Lin,
Feng Wen,
Zhuo Li,
Hao Dai,
Renwei Huang,
Zhonglin Feng,
Zhilian Li,
Shuangxin Liu,
Lixia Xu

Affiliations

Sijia Li: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Shuting Deng: School of Medicine, South China University of Technology, Guangzhou, China
Sichun Wen: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Siqi Peng: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Nan Jiang: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Bohou Li: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Boxi Chen: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Ye Yuan: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Qiong Wu: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Yiming Tao: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Jianchao Ma: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Ting Lin: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Feng Wen: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Zhuo Li: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Hao Dai: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Renwei Huang: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Zhonglin Feng: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Zhilian Li: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Shuangxin Liu: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Lixia Xu: Department of Nephrology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

DOI: https://doi.org/10.1159/000538033
Journal volume & issue: Vol. 14, no. 1
pp. 42 – 47

Abstract

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Introduction: Refractory lupus nephritis (LN) causes kidney disease progression and increases the risk of loss of renal function. Due to the high specificity and few side effects of biological agents, they are recommended for the treatment of systemic lupus erythematosus. There are few data on telitacicept for the treatment of refractory LN. Case Presentation: Here, we report the efficacy and safety of telitacicept in the treatment of refractory LN in a 25-year-old female patient. This patient with refractory lupus developed Pneumocystis jirovecii pneumonia while using multitargeted therapy, and the patient’s urine protein was rapidly relieved after telitacicept combination with low-dose mycophenolate mofetil (MMF). Conclusion: This result suggests that telitacicept has a positive effect on refractory LN with no significant side effects. Further reports and a registry are necessary to confirm that telitacicept with low-dose MMF should be preferred in refractory LN.

Published in Case Reports in Nephrology and Dialysis

ISSN: 2296-9705 (Online)
Publisher: Karger Publishers
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: https://www.karger.com/Journal/Home/254804

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