South Asian Journal of Cancer (Apr 2022)

Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report

  • Goranthala Bharathi Devi,
  • Perumal Kalaiyarasi Jayachandran,
  • Jhansi Rani Arumugam,
  • Karthik Bommannan,
  • Shirley Sundersingh

DOI
https://doi.org/10.1055/s-0041-1739178
Journal volume & issue
Vol. 11, no. 02
pp. 175 – 177

Abstract

Read online

Abstract Perumal Kalaiyarasi Jayachandran Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation (BCR-ABL1) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs) start appearing. Although relatively rare, chromosomal abnormalities can exist or develop in the Philadelphia (Ph)-negative clones, which may lead to the evolution of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). We hereby present a case of AML which emerged from a Ph-negative clone in a patient with a history of CML who was in deep molecular response. The possible mechanisms of ACAs have been discussed.

Keywords