ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

Su Hyung Park; Nalae Kang; Eunho Song; Minwoo Wie; Eun A. Lee; Sunyoung Hwang; Deokjae Lee; Jae Sun Ra; In Bae Park; Jieun Park; Sukhyun Kang; Jun Hong Park; Sungchul Hohng; Kyoo-young Lee; Kyungjae Myung

doi:10.1038/s41467-019-13667-4

Nature Communications (Dec 2019)

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

Su Hyung Park,
Nalae Kang,
Eunho Song,
Minwoo Wie,
Eun A. Lee,
Sunyoung Hwang,
Deokjae Lee,
Jae Sun Ra,
In Bae Park,
Jieun Park,
Sukhyun Kang,
Jun Hong Park,
Sungchul Hohng,
Kyoo-young Lee,
Kyungjae Myung

Affiliations

Su Hyung Park: Center for Genomic Integrity, Institute for Basic Science
Nalae Kang: Center for Genomic Integrity, Institute for Basic Science
Eunho Song: Interdisciplinary Graduate Program in Biophysics and Chemical Biology, Seoul National University
Minwoo Wie: Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology
Eun A. Lee: Center for Genomic Integrity, Institute for Basic Science
Sunyoung Hwang: Center for Genomic Integrity, Institute for Basic Science
Deokjae Lee: Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology
Jae Sun Ra: Center for Genomic Integrity, Institute for Basic Science
In Bae Park: Center for Genomic Integrity, Institute for Basic Science
Jieun Park: Center for Genomic Integrity, Institute for Basic Science
Sukhyun Kang: Center for Genomic Integrity, Institute for Basic Science
Jun Hong Park: Center for Genomic Integrity, Institute for Basic Science
Sungchul Hohng: Interdisciplinary Graduate Program in Biophysics and Chemical Biology, Seoul National University
Kyoo-young Lee: Center for Genomic Integrity, Institute for Basic Science
Kyungjae Myung: Center for Genomic Integrity, Institute for Basic Science

DOI: https://doi.org/10.1038/s41467-019-13667-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51/PCNA regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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