Nature Communications (Aug 2020)
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
- Shipo Wu,
- Gongxun Zhong,
- Jun Zhang,
- Lei Shuai,
- Zhe Zhang,
- Zhiyuan Wen,
- Busen Wang,
- Zhenghao Zhao,
- Xiaohong Song,
- Yi Chen,
- Renqiang Liu,
- Ling Fu,
- Jinlong Zhang,
- Qiang Guo,
- Chong Wang,
- Yilong Yang,
- Ting Fang,
- Peng Lv,
- Jinliang Wang,
- Junjie Xu,
- Jianmin Li,
- Changming Yu,
- Lihua Hou,
- Zhigao Bu,
- Wei Chen
Affiliations
- Shipo Wu
- Beijing Institute of Biotechnology
- Gongxun Zhong
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Jun Zhang
- Beijing Institute of Biotechnology
- Lei Shuai
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Zhe Zhang
- Beijing Institute of Biotechnology
- Zhiyuan Wen
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Busen Wang
- Beijing Institute of Biotechnology
- Zhenghao Zhao
- Beijing Institute of Biotechnology
- Xiaohong Song
- Beijing Institute of Biotechnology
- Yi Chen
- Beijing Institute of Biotechnology
- Renqiang Liu
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Ling Fu
- Beijing Institute of Biotechnology
- Jinlong Zhang
- Beijing Institute of Biotechnology
- Qiang Guo
- Beijing Institute of Biotechnology
- Chong Wang
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Yilong Yang
- Beijing Institute of Biotechnology
- Ting Fang
- Beijing Institute of Biotechnology
- Peng Lv
- Beijing Institute of Biotechnology
- Jinliang Wang
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Junjie Xu
- Beijing Institute of Biotechnology
- Jianmin Li
- Beijing Institute of Biotechnology
- Changming Yu
- Beijing Institute of Biotechnology
- Lihua Hou
- Beijing Institute of Biotechnology
- Zhigao Bu
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
- Wei Chen
- Beijing Institute of Biotechnology
- DOI
- https://doi.org/10.1038/s41467-020-17972-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 7
Abstract
A vaccine preventing infection and transmission of SARS-CoV-2 is needed. Here, Wu et al. generate an adenovirus-vector vaccine expressing SARS-CoV-2 spike protein and show that a single dose of mucosal vaccination protects mice and ferrets from infection and inhibits virus replication in the upper respiratory tract.
