CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis

Xiang Guo; Ann Dean

doi:10.1186/s13059-018-1569-z

Genome Biology (Nov 2018)

CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis

Xiang Guo,
Ann Dean

Affiliations

Xiang Guo: Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Ann Dean: Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

DOI: https://doi.org/10.1186/s13059-018-1569-z
Journal volume & issue: Vol. 19, no. 1
pp. 1 – 3

Abstract

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Abstract A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.

Published in Genome Biology

ISSN: 1474-760X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://genomebiology.biomedcentral.com/

About the journal