Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life

Abstract

The role of stem/progenitor cell populations in mammary gland morphogenesis is not well understood. Here, the authors show that a transcriptional repressor, Blimp1, is expressed in a rare luminal stem cell population, which contribute to duct formation, and survive multiple rounds of pregnancy and involution.