Nature Communications (Jun 2020)

Orbitofrontal control of visual cortex gain promotes visual associative learning

  • Dechen Liu,
  • Juan Deng,
  • Zhewei Zhang,
  • Zhi-Yu Zhang,
  • Yan-Gang Sun,
  • Tianming Yang,
  • Haishan Yao

DOI
https://doi.org/10.1038/s41467-020-16609-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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The orbitofrontal cortex (OFC) encodes expected outcomes and plays a key role in outcome-guided behavior. The authors show here that the top-down projection from the OFC to the visual cortex drives visual associative learning by modulating the response gain of V1 neurons to non-relevant stimuli.