Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity

Yvonne Rericha; Dunping Cao; Lisa Truong; Michael T. Simonich; Jennifer A. Field; Robyn L. Tanguay

iScience (Feb 2022)

Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity

Yvonne Rericha,
Dunping Cao,
Lisa Truong,
Michael T. Simonich,
Jennifer A. Field,
Robyn L. Tanguay

Affiliations

Yvonne Rericha: Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA; Sinnhuber Aquatic Research Laboratory, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA
Dunping Cao: Department of Chemistry, College of Science, Oregon State University, Corvallis, OR 97333, USA
Lisa Truong: Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA; Sinnhuber Aquatic Research Laboratory, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA
Michael T. Simonich: Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA; Sinnhuber Aquatic Research Laboratory, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA
Jennifer A. Field: Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA
Robyn L. Tanguay: Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA; Sinnhuber Aquatic Research Laboratory, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97333, USA; Corresponding author

Journal volume & issue: Vol. 25, no. 2
p. 103789

Abstract

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Summary: Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in environmental and biological samples and cause adverse health effects. Studies have predominately focused on long-chain PFAS, with far fewer addressing short-chain alternatives. This study leveraged embryonic zebrafish to investigate developmental toxicity of a short-chain series: perfluorobutane sulfonate (PFBS), perfluoropentanoic acid (PFPeA), perfluorobutane sulfonamide (FBSA), and 4:2 fluorotelomer sulfonic acid (4:2 FTS). Following static exposures at 8 h postfertilization (hpf) to each chemical (1–100 μM), morphological and behavioral endpoints were assessed at 24 and 120 hpf. Only FBSA induced abnormal morphology, while exposure to all chemicals caused aberrant larval behavior. RNA sequencing at 48 hpf following 47 μM exposures revealed only FBSA significantly disrupted normal gene expression. Measured tissue concentrations were FBSA > PFBS > 4:2 FTS > PFPeA. This study demonstrates functional head groups impact bioactivity and bioconcentration.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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