Emerging Infectious Diseases (Jun 2015)
Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
- J.W.M. van der Linden,
- M.C. Arendrup,
- A. Warris,
- K. Lagrou,
- H. Pelloux,
- P.M. Hauser,
- E. Chryssanthou,
- E. Mellado,
- S.E. Kidd,
- A.M. Tortorano,
- E. Dannaoui,
- P. Gaustad,
- J.W. Baddley,
- A. Uekötter,
- C. Lass-Flörl,
- N. Klimko,
- C.B. Moore,
- D.W. Denning,
- A.C. Pasqualotto,
- C. Kibbler,
- S. Arikan-Akdagli,
- D. Andes,
- J. Meletiadis,
- L. Naumiuk,
- M. Nucci,
- W.J.G. Melchers,
- P.E. Verweij
Affiliations
- J.W.M. van der Linden
- M.C. Arendrup
- A. Warris
- K. Lagrou
- H. Pelloux
- P.M. Hauser
- E. Chryssanthou
- E. Mellado
- S.E. Kidd
- A.M. Tortorano
- E. Dannaoui
- P. Gaustad
- J.W. Baddley
- A. Uekötter
- C. Lass-Flörl
- N. Klimko
- C.B. Moore
- D.W. Denning
- A.C. Pasqualotto
- C. Kibbler
- S. Arikan-Akdagli
- D. Andes
- J. Meletiadis
- L. Naumiuk
- M. Nucci
- W.J.G. Melchers
- P.E. Verweij
- DOI
- https://doi.org/10.3201/eid2106.140717
- Journal volume & issue
-
Vol. 21,
no. 6
pp. 1041 – 1044
Abstract
To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
Keywords
