A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

Einat Seidel; Liat Dassa; Shira Kahlon; Boaz Tirosh; Anne Halenius; Tal Seidel Malkinson; Ofer Mandelboim

doi:10.1038/s41467-021-21983-x

Nature Communications (Apr 2021)

A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

Einat Seidel,
Liat Dassa,
Shira Kahlon,
Boaz Tirosh,
Anne Halenius,
Tal Seidel Malkinson,
Ofer Mandelboim

Affiliations

Einat Seidel: The Lautenberg Center for General and Tumor Immunology, The Faculty of Medicine, The Hebrew University Medical School, IMRIC
Liat Dassa: The Lautenberg Center for General and Tumor Immunology, The Faculty of Medicine, The Hebrew University Medical School, IMRIC
Shira Kahlon: The Lautenberg Center for General and Tumor Immunology, The Faculty of Medicine, The Hebrew University Medical School, IMRIC
Boaz Tirosh: The Institute for Drug Research, Hebrew University Faculty of Medicine, Hebrew University of Jerusalem
Anne Halenius: Institute of Virology, Medical Center University of Freiburg
Tal Seidel Malkinson: Paris Brain Institute, Sorbonne Université, Inserm UMRS 1127, CNRS UMR 7225
Ofer Mandelboim: The Lautenberg Center for General and Tumor Immunology, The Faculty of Medicine, The Hebrew University Medical School, IMRIC

DOI: https://doi.org/10.1038/s41467-021-21983-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Glycoprotein US9 of human cytomegalovirus downregulates the activating immune ligand MICA*008 to avoid NK cell activation. Here, Seidel et al. show that the signal peptide of US9 is cleaved unusually slowly, causing MICA*008 to be retained in the endoplasmic reticulum (ER) and degraded via the ER quality control system.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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