Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Chris H. Hill; Lukas Pekarek; Sawsan Napthine; Anuja Kibe; Andrew E. Firth; Stephen C. Graham; Neva Caliskan; Ian Brierley

doi:10.1038/s41467-021-27400-7

Nature Communications (Dec 2021)

Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Chris H. Hill,
Lukas Pekarek,
Sawsan Napthine,
Anuja Kibe,
Andrew E. Firth,
Stephen C. Graham,
Neva Caliskan,
Ian Brierley

Affiliations

Chris H. Hill: Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road
Lukas Pekarek: Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI)
Sawsan Napthine: Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road
Anuja Kibe: Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI)
Andrew E. Firth: Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road
Stephen C. Graham: Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road
Neva Caliskan: Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI)
Ian Brierley: Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road

DOI: https://doi.org/10.1038/s41467-021-27400-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Many RNA viruses employ programmed –1 ribosomal frameshifting (PRF) to expand their coding capacity and optimize production of viral proteins. Here, the authors report structural and biophysical analysis of protein 2A from a cardiovirus, with insights into the mechanism of its PRF-stimulatory function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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