Selected Issues of the Pathogenesis and Intensive Treatment of Severe Contaminant Injury

Abstract

The paper gives the results of a number of Russian studies in the past 10 years on the pathogenesis of severe concomitant injury accompanied by shock and blood loss and development of its new treatment options. In particular, it considers new experimental and clinical data on changes in hormonal status, lipid metabolism, hemorheology, microcirculation, oxidant-antioxidant balance, neuroimmune endocrine system, and oxygen transport. At the same time the respective pathogenetic principles in the treatment of patients and victims are justified, with special emphasis on the use of antihypoxants and prospects for efferent therapeutic techniques. There are also papers on the pathogenesis and correction of hypoxia in individual categories of trauma patients, those with blunt chest injury and mine blast victims in particular.

Keywords

• trauma
• blood loss
• shock
• perfluorane