Nature Communications (Jan 2021)
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
- Mylène Tajan,
- Marc Hennequart,
- Eric C. Cheung,
- Fabio Zani,
- Andreas K. Hock,
- Nathalie Legrave,
- Oliver D. K. Maddocks,
- Rachel A. Ridgway,
- Dimitris Athineos,
- Alejandro Suárez-Bonnet,
- Robert L. Ludwig,
- Laura Novellasdemunt,
- Nikolaos Angelis,
- Vivian S. W. Li,
- Georgios Vlachogiannis,
- Nicola Valeri,
- Nello Mainolfi,
- Vipin Suri,
- Adam Friedman,
- Mark Manfredi,
- Karen Blyth,
- Owen J. Sansom,
- Karen H. Vousden
Affiliations
- Mylène Tajan
- The Francis Crick Institute
- Marc Hennequart
- The Francis Crick Institute
- Eric C. Cheung
- The Francis Crick Institute
- Fabio Zani
- The Francis Crick Institute
- Andreas K. Hock
- Cancer Research UK Beatson Institute
- Nathalie Legrave
- The Francis Crick Institute
- Oliver D. K. Maddocks
- Institute of Cancer Sciences, University of Glasgow
- Rachel A. Ridgway
- Cancer Research UK Beatson Institute
- Dimitris Athineos
- Cancer Research UK Beatson Institute
- Alejandro Suárez-Bonnet
- The Royal Veterinary College
- Robert L. Ludwig
- The Francis Crick Institute
- Laura Novellasdemunt
- The Francis Crick Institute
- Nikolaos Angelis
- The Francis Crick Institute
- Vivian S. W. Li
- The Francis Crick Institute
- Georgios Vlachogiannis
- Gastrointestinal Cancer Biology and Genomics Team, Centre for Evolution and Cancer, The Institute of Cancer Research
- Nicola Valeri
- Gastrointestinal Cancer Biology and Genomics Team, Centre for Evolution and Cancer, The Institute of Cancer Research
- Nello Mainolfi
- Raze Therapeutics, Inc.
- Vipin Suri
- Raze Therapeutics, Inc.
- Adam Friedman
- Raze Therapeutics, Inc.
- Mark Manfredi
- Raze Therapeutics, Inc.
- Karen Blyth
- Cancer Research UK Beatson Institute
- Owen J. Sansom
- Cancer Research UK Beatson Institute
- Karen H. Vousden
- The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-020-20223-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models.
