S253: THE SHEDDASE DOMAIN OF ADAM10 AUGMENTS THE INTERACTION OF LEUKEMIA CELLS WITH THE BONE MARROW NICHE IN VIVO AS SHOWN BY RECONSTITUTING PDX LEUKEMIA CELLS WITH CRISPR-CAS9-INDUCED KNOCKOUT

• J. P. Schmid,
• E. Bahrami,
• M. Becker,
• A. K. Jayavelu,
• A.-K. Wirth,
• V. Jurinovic,
• R. Öllinger,
• R Rad,
• B. Vick,
• M. Mann,
• T. Herold,
• I. Jeremias

Affiliations

J. P. Schmid

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

E. Bahrami

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

M. Becker

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

A. K. Jayavelu

3 Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried

A.-K. Wirth

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

V. Jurinovic

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

R. Öllinger

6 Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Technische Universität München

R Rad

2 German Cancer Consortium (DKTK), partner site Munich, Munich

B. Vick

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

M. Mann

3 Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried

T. Herold

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)

I. Jeremias

1 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU)