THE ROLE OF ALLELIC POLYMORPHISM OF RECEPTOR GENES OF INNATE IMMUNITY IN THE PERSISTENCE OF HUMAN PAPILLOMAVIRUS

Abstract

The development of a stable immunoresistance against human papillomavirus occurs largely due to the reactions of the innate immune system, mediated through Toll-like receptors. It is known, that allelic polymorphism of the Toll-like receptors genes, associated with single nucleotide polymorphisms can influence on the sensitivity of reception and lead to disruption of pathogen recognition and, thus lead to reduced susceptibility of the body to infectious agents. The aim of the study was to find the association of polymorphisms T-1237S, A2848G of TLR 9 gene, Phe-412 Leu of TLR 3 gene and С-819 Т, G-1082 A of IL-10 gene with persistence of human papillomavirus infection of high oncogenic types. There were examined 194 women aged 18–42 years with the presence of HPV types 16 and 18. The material for laboratory studies were scraped from the mucosa of the urogenital tract and peripheral blood of patients. Depending on the presence of virus women were divided into two groups: 98 patients with persistent human papillomavirus infection and 96 women without it. As the result after investigation some significant differences in the distribution of variants of polymorphic loci (A2848G) TLR 9, (Phe412 Leu) TLR 3 and (G-1082A) IL-10 were identified.

Keywords

• human papillomavirus
• polymorphism
• tolllike receptor