The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

Fenglei Li; Xiaolei Hao; Yongyan Chen; Li Bai; Xiang Gao; Zhexiong Lian; Haiming Wei; Rui Sun; Zhigang Tian

doi:10.1038/ncomms13839

Nature Communications (Jan 2017)

The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

Fenglei Li,
Xiaolei Hao,
Yongyan Chen,
Li Bai,
Xiang Gao,
Zhexiong Lian,
Haiming Wei,
Rui Sun,
Zhigang Tian

Affiliations

Fenglei Li: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China
Xiaolei Hao: Hefei National Laboratory for Physical Sciences at Microscale
Yongyan Chen: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China
Li Bai: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China
Xiang Gao: Model Animal Research Center, Nanjing University
Zhexiong Lian: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China
Haiming Wei: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China
Rui Sun: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China
Zhigang Tian: Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), School of Life Science and Medical Center, University of Science and Technology of China

DOI: https://doi.org/10.1038/ncomms13839
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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γδ T cells are major producers of IL-17A in response to microbial infection. Here the authors show that a high load of commensal microbes can maintain homeostasis of IL-17A+γδ T cells in the liver via CD1d antigen presentation, with implications for liver diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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