Nature Communications (Jul 2021)
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
- Silvia Martinelli,
- Elmira A. Anderzhanova,
- Thomas Bajaj,
- Svenja Wiechmann,
- Frederik Dethloff,
- Katja Weckmann,
- Daniel E. Heinz,
- Tim Ebert,
- Jakob Hartmann,
- Thomas M. Geiger,
- Michael Döngi,
- Kathrin Hafner,
- Max L. Pöhlmann,
- Lee Jollans,
- Alexandra Philipsen,
- Susanne V. Schmidt,
- Ulrike Schmidt,
- Giuseppina Maccarrone,
- Valentin Stein,
- Felix Hausch,
- Christoph W. Turck,
- Mathias V. Schmidt,
- Anne-Kathrin Gellner,
- Bernhard Kuster,
- Nils C. Gassen
Affiliations
- Silvia Martinelli
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Elmira A. Anderzhanova
- Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn
- Thomas Bajaj
- Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn
- Svenja Wiechmann
- Chair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5
- Frederik Dethloff
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Katja Weckmann
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Daniel E. Heinz
- Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn
- Tim Ebert
- Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn
- Jakob Hartmann
- Department of Psychiatry, Harvard Medical School and McLean Hospital
- Thomas M. Geiger
- Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt
- Michael Döngi
- Institut für Physiologie II, University of Bonn
- Kathrin Hafner
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Max L. Pöhlmann
- Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry
- Lee Jollans
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Alexandra Philipsen
- Department of Psychiatry and Psychotherapy, University of Bonn
- Susanne V. Schmidt
- Institute of Innate Immunity, University of Bonn
- Ulrike Schmidt
- Research Group Molecular and Clinical Psychotraumatology, Department of Psychiatry and Psychotherapy, Rheinische Friedrich-Wilhelms-Universität Bonn
- Giuseppina Maccarrone
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Valentin Stein
- Institut für Physiologie II, University of Bonn
- Felix Hausch
- Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt
- Christoph W. Turck
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Mathias V. Schmidt
- Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry
- Anne-Kathrin Gellner
- Institut für Physiologie II, University of Bonn
- Bernhard Kuster
- Chair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5
- Nils C. Gassen
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- DOI
- https://doi.org/10.1038/s41467-021-24810-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic plasticity.
