Frontiers in Neurology (Jul 2024)
Paramagnetic rim lesions as a biomarker to discriminate between multiple sclerosis and cerebral small vessel disease
- Zhibao Zhu,
- Zhibao Zhu,
- Zhibao Zhu,
- Zhibao Zhu,
- Yuanyuan Zhang,
- Yuanyuan Zhang,
- Yuanyuan Zhang,
- Chun Li,
- Chun Li,
- Chun Li,
- Wenliang Guo,
- Wenliang Guo,
- Zhili Chen,
- Zhili Chen,
- Zhili Chen,
- Wei Chen,
- Wei Chen,
- Wei Chen,
- Shaowu Li,
- Ning Wang,
- Ning Wang,
- Ning Wang,
- Xiaochun Chen,
- Xiaochun Chen,
- Ying Fu,
- Ying Fu,
- Ying Fu
Affiliations
- Zhibao Zhu
- Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
- Zhibao Zhu
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Zhibao Zhu
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Zhibao Zhu
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- Yuanyuan Zhang
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Yuanyuan Zhang
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Yuanyuan Zhang
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- Chun Li
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Chun Li
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Chun Li
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- Wenliang Guo
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Wenliang Guo
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Zhili Chen
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Zhili Chen
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Zhili Chen
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- Wei Chen
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Wei Chen
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Wei Chen
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- Shaowu Li
- Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Ning Wang
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Ning Wang
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Ning Wang
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- Xiaochun Chen
- Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
- Xiaochun Chen
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Ying Fu
- Department of Neurology, Fujian Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
- Ying Fu
- Fujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China
- Ying Fu
- Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
- DOI
- https://doi.org/10.3389/fneur.2024.1429698
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundMultiple sclerosis (MS) and Cerebral Small Vessel Disease (CSVD) exhibit some similarities in Magnetic resonance imaging (MRI), potentially leading to misdiagnosis and delaying effective treatment windows. It is unclear whether CSVD can be detected with Paramagnetic Rim Lesions (PRL), which is special in MS.ObjectiveWe aimed to investigate whether PRL can serve as a neuroimaging marker for discriminating between MS and CSVD.MethodsIn this retrospective study, 49 MS and 104 CSVD patients underwent 3.0 T Magnetic resonance imaging (MRI). Visual assessment of 37 MS patients and 89 CSVD patients with or without lacunes, cerebral microbleeds (CMBs), enlarged perivascular spaces (EPVS), white matter hyperintensity (WMH), central vein sign (CVS), and PRL. The distribution and number of PRL were then counted.ResultsOur study found that PRL was detected in over half of the MS patients but was entirely absent in CSVD patients (78.38 vs. 0%, p < 0.0001), and PRL showed high specificity with good sensitivity in discriminating between MS and CSVD (sensitivity: 78.38%, specificity: 100%, AUC: 0.96).ConclusionParamagnetic Rim Lesions is a special imaging feature in MS, absent in CSVD. Detection of PRL can be very helpful in the clinical management of MS and CSVD.
Keywords
- paramagnetic rim lesions
- multiple sclerosis
- cerebral small vessel disease
- magnetic resonance imaging
- biomarker
