Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

Elodie Persyn; Ken B. Hanscombe; Joanna M. M. Howson; Cathryn M. Lewis; Matthew Traylor; Hugh S. Markus

doi:10.1038/s41467-020-15932-3

Nature Communications (May 2020)

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

Elodie Persyn,
Ken B. Hanscombe,
Joanna M. M. Howson,
Cathryn M. Lewis,
Matthew Traylor,
Hugh S. Markus

Affiliations

Elodie Persyn: Department of Medical and Molecular Genetics, King’s College London
Ken B. Hanscombe: Department of Medical and Molecular Genetics, King’s College London
Joanna M. M. Howson: BHF, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
Cathryn M. Lewis: Department of Medical and Molecular Genetics, King’s College London
Matthew Traylor: Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge
Hugh S. Markus: Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge

DOI: https://doi.org/10.1038/s41467-020-15932-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Cerebral small vessel disease (CSVD) is a major cause of stroke and associated with structural changes of the brain. Here, Persyn et al. perform genome-wide association studies for magnetic resonance imaging (MRI) markers of CSVD, explore genetic correlations and prioritize candidate genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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