Comparing the effect of 6 weeks of continuous and interval aerobic training on vascular endothelial growth factor and superoxide dismutase enzyme in hippocampus of male rats of Parkinson\'s model

Abstract

Introdution: Based on researches, increased levels of vascular endothelial growth factor and antioxidant parameters in areas of the brain that are more affected by Parkinson's disease have a potential therapeutic effect. Therefore, the purpose of this study was to compare the effect of 6 weeks continuous and interval aerobic exercises on vascular endothelial growth factor and superoxide dismutase enzyme; Parkinson's rats. Methods: In this experimental study, 24 male Wistar male rats (12 weeks) with an average weight of 250 to 350 grams were used. Subjects were treated with reserpine to Parkinson's, then divided into 6 groups. Aerobic exercises were performed for 6 weeks. After 48 hours of the last training session, the rats were killed, then the tissue of the hippocampus was separated from other parts of the brain, and vascular endothelial growth factor and superoxide dismutase enzyme were measured using specific kits. The results were analyzed using one way analysis of variance analysis and Bonferroni post hoc test. Results: The results of this study showed that 6 weeks of continuous and interval aerobic exercise increased vascular endothelial growth factor levels in Parkinson's rats (p = 0.01). There was no significant difference between the two groups of interval exercises compared to the continuous training group (p = 0.87). Also, these exercises did not significantly affect the superoxide dismutase enzymes (p = 0.47). Conclusion: Based on the findings of this study, it has been shown that 6 weeks of continuous and periodic aerobic exercise increases the vascular endothelial growth factor, but these exercises have not significantly changed the superoxide dismutase enzyme.

Keywords

• Parkinson's
• Superoxide Dismutase
• Vascular Endothelial Growth Factors