Haematologica (Nov 2008)

Prognostic factors for thrombosis, myelofibrosis, and leukemia in essential thrombocythemia: a study of 605 patients

  • Francesco Passamonti,
  • Elisa Rumi,
  • Luca Arcaini,
  • Emanuela Boveri,
  • Chiara Elena,
  • Daniela Pietra,
  • Sabrina Boggi,
  • Cesare Astori,
  • Paolo Bernasconi,
  • Marzia Varettoni,
  • Ercole Brusamolino,
  • Cristiana Pascutto,
  • Mario Lazzarino

DOI
https://doi.org/10.3324/haematol.13346
Journal volume & issue
Vol. 93, no. 11

Abstract

Read online

Background Essential thrombocythemia is a chronic myeloproliferative disorder; patients with this disorder have a propensity to develop thrombosis, myelofibrosis, and leukemia.Design and Methods We studied 605 patients with essential thrombocythemia (follow-up 4596 person-years) with the aim of defining prognostic factors for thrombosis, myelofibrosis, and leukemia during follow-up.Results Sixty-six patients (11%) developed thrombosis with a 10-year risk of 14%. Age >60 years (p60 years (p