THE PECULIARITY OF PSEUDOMONAS AERUGINOSA ATCC 27853 BIOFILM FORMATION AT THE DARK OR PHOTOINDUCED ACTION OF BISMUTH-CONTAINING PORPHYRINS

Abstract

Bismuth complexes of the meso-tetra(4-N-methyl)-pirydylporphyrin, meso-tetra(6-N-methyl)-quinolinylporphyrin inhibit biofilm formation, alginate synthesis and planktonic culture growth by Pseudomonas aeruginosa ATCC 27853 in dependence of the dose. In concentration of the 80 mM these markers decreased for 85–98% in presence of the Bi3+-ÒPP, and for 50–82% – Bi3+-ÒHP. In contrast with meso-substituted porphyrins, protoporphyrin IX bismuth-complex action was not dependent from a concentration and was not higher then 50–60%. Biofilm formation process was repressed higher in presence of the photoactivated compounds. Instead this, dark action were prevailed to photoinduced on the planktonic culture biomass and alginate synthesis. Only in presents of the concentrations 40 and 80 mM Bi3+-ÒPP, and Bi3+-ÒHP higher (in 1.2–2 times) inhibit planktonic culture biomass after photoactivation.

Keywords

• біоплівка pseudomonas aeruginosa atcc 27853
• вісмутові металокомплекси порфіринів
• темнова та фотоіндукована дія