Foods (May 2020)

An Infant Milk Formula Supplemented with Heat-Treated Probiotic <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> CECT 8145, Reduces Fat Deposition in <i>C. elegans</i> and Augments Acetate and Lactate in a Fermented Infant Slurry

  • Ángela Silva,
  • Nuria Gonzalez,
  • Ana Terrén,
  • Antonio García,
  • Juan Francisco Martinez-Blanch,
  • Vanessa Illescas,
  • Javier Morales,
  • Marcos Maroto,
  • Salvador Genovés,
  • Daniel Ramón,
  • Patricia Martorell,
  • Empar Chenoll

DOI
https://doi.org/10.3390/foods9050652
Journal volume & issue
Vol. 9, no. 5
p. 652

Abstract

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Pediatric obesity has a growing health and socio-economical impact due to cardiovascular and metabolic complications in adult life. Some recent studies suggest that live or heat-treated probiotics have beneficial effects in preventing fat deposition and obesity in preclinical and clinical sets. Here, we have explored the effects of heat-treated probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (HT-BPL1), added as a supplement on an infant milk formula (HT-BPL1-IN), on Caenorhabditis elegans fat deposition and short-chain fatty acids (SCFAs) and lactate, using fermented baby fecal slurries. We have found that HT-BPL1-IN significantly reduced fat deposition in C. elegans, at the time it drastically augmented the generation of some SCFAs, particulary acetate and organic acid lactate. Data suggest that heat-treated BPL1 maintains its functional activities when added to an infant powder milk formula.

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