Catalyst-free ultrasound assisted novel one pot pseudo five component synthesis of aryl-bis-[1H-pyrazol-5-ol-4-yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4-yl]methanes and their 1-phenyl derivatives in aqueous medium

Abstract

An efficient, catalyst-free and eco-friendly ultrasound-assisted novel one-pot pseudo-five-component synthesis of aryl-bis-[1H-pyrazol-5-ol-4yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4yl]methanes and their 1-phenyl derivatives in water is reported. The products were obtained in excellent yield in shorter duration with high purity, by simple filtration. This synthetic methodology has been optimized and discussed herein.

Keywords

• Bis pyrozolyl-methanes
• Ethyl acetoacetate
• Aromatic/het (aryl) aldehydes
• Hydrazine/phenyl hydrazine
• One-pot multi-component synthesis
• Ultrasound