PLoS ONE (Jan 2011)

LINGO1 variants in the French-Canadian population.

  • Cynthia V Bourassa,
  • Jean-Baptiste Rivière,
  • Patrick A Dion,
  • Geneviève Bernard,
  • Sabrina Diab,
  • Michel Panisset,
  • Sylvain Chouinard,
  • Nicolas Dupré,
  • Hélène Fournier,
  • John Raelson,
  • Majid Belouchi,
  • Guy A Rouleau

DOI
https://doi.org/10.1371/journal.pone.0016254
Journal volume & issue
Vol. 6, no. 1
p. e16254

Abstract

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Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).