Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum

Marco D. Carpenter; Delaney K. Fischer; Shuo Zhang; Allison M. Bond; Kyle S. Czarnecki; Morgan T. Woolf; Hongjun Song; Elizabeth A. Heller

doi:10.1038/s41467-022-35384-1

Nature Communications (Dec 2022)

Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum

Marco D. Carpenter,
Delaney K. Fischer,
Shuo Zhang,
Allison M. Bond,
Kyle S. Czarnecki,
Morgan T. Woolf,
Hongjun Song,
Elizabeth A. Heller

Affiliations

Marco D. Carpenter: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Delaney K. Fischer: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Shuo Zhang: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Allison M. Bond: Department of Neuroscience, University of Pennsylvania
Kyle S. Czarnecki: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Morgan T. Woolf: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Hongjun Song: Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania
Elizabeth A. Heller: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-022-35384-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Bulk or pooled epigenomic profiling in the heterogenous brain obscures cell-type-specificity and individual subject variability in gene regulation. Here the authors optimized a hybrid protocol, ICuRuS, to profile epigenetic features in neuronal subtypes from a single mouse.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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