Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation

Po-Ting Liu; Brandon F. Keele; Peter Abbink; Noe B. Mercado; Jinyan Liu; Esther A. Bondzie; Abishek Chandrashekar; Erica N. Borducchi; Joseph Hesselgesser; Michael Mish; Gregory Chin; Elena Bekerman; Romas Geleziunas; Dan H. Barouch

doi:10.1038/s41467-020-19254-2

Nature Communications (Oct 2020)

Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation

Po-Ting Liu,
Brandon F. Keele,
Peter Abbink,
Noe B. Mercado,
Jinyan Liu,
Esther A. Bondzie,
Abishek Chandrashekar,
Erica N. Borducchi,
Joseph Hesselgesser,
Michael Mish,
Gregory Chin,
Elena Bekerman,
Romas Geleziunas,
Dan H. Barouch

Affiliations

Po-Ting Liu: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Brandon F. Keele: AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research
Peter Abbink: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Noe B. Mercado: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jinyan Liu: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Esther A. Bondzie: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Abishek Chandrashekar: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Erica N. Borducchi: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Joseph Hesselgesser: Gilead Sciences
Michael Mish: Gilead Sciences
Gregory Chin: Gilead Sciences
Elena Bekerman: Gilead Sciences
Romas Geleziunas: Gilead Sciences
Dan H. Barouch: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-19254-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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The origin and nature of rebound HIV-1 virus following antiretroviral therapy (ART) discontinuation still remains unclear. Here, Liu et al. suggest that intact proviral DNA in peripheral blood and lymph node mononuclear cells during ART suppression likely is the source of viral rebound following ART discontinuation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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