Nature Communications (Oct 2022)
Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease
- Hong Yuen Wong,
- Quanhu Sheng,
- Amanda B. Hesterberg,
- Sarah Croessmann,
- Brenda L. Rios,
- Khem Giri,
- Jorgen Jackson,
- Adam X. Miranda,
- Evan Watkins,
- Kerry R. Schaffer,
- Meredith Donahue,
- Elizabeth Winkler,
- David F. Penson,
- Joseph A. Smith,
- S. Duke Herrell,
- Amy N. Luckenbaugh,
- Daniel A. Barocas,
- Young J. Kim,
- Diana Graves,
- Giovanna A. Giannico,
- Jeffrey C. Rathmell,
- Ben H. Park,
- Jennifer B. Gordetsky,
- Paula J. Hurley
Affiliations
- Hong Yuen Wong
- Department of Medicine, Vanderbilt University Medical Center
- Quanhu Sheng
- Department of Biostatistics, Vanderbilt University Medical Center
- Amanda B. Hesterberg
- Department of Medicine, Vanderbilt University Medical Center
- Sarah Croessmann
- Department of Medicine, Vanderbilt University Medical Center
- Brenda L. Rios
- Department of Medicine, Vanderbilt University Medical Center
- Khem Giri
- Department of Medicine, Vanderbilt University Medical Center
- Jorgen Jackson
- Department of Medicine, Vanderbilt University Medical Center
- Adam X. Miranda
- Department of Medicine, Vanderbilt University Medical Center
- Evan Watkins
- Department of Medicine, Vanderbilt University Medical Center
- Kerry R. Schaffer
- Department of Medicine, Vanderbilt University Medical Center
- Meredith Donahue
- Department of Urology, Vanderbilt University Medical Center
- Elizabeth Winkler
- Department of Urology, Vanderbilt University Medical Center
- David F. Penson
- Vanderbilt-Ingram Cancer Center
- Joseph A. Smith
- Department of Urology, Vanderbilt University Medical Center
- S. Duke Herrell
- Department of Urology, Vanderbilt University Medical Center
- Amy N. Luckenbaugh
- Department of Urology, Vanderbilt University Medical Center
- Daniel A. Barocas
- Department of Urology, Vanderbilt University Medical Center
- Young J. Kim
- Vanderbilt-Ingram Cancer Center
- Diana Graves
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Giovanna A. Giannico
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Jeffrey C. Rathmell
- Vanderbilt-Ingram Cancer Center
- Ben H. Park
- Department of Medicine, Vanderbilt University Medical Center
- Jennifer B. Gordetsky
- Vanderbilt-Ingram Cancer Center
- Paula J. Hurley
- Department of Medicine, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-33780-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
The molecular and cellular underpinnings of cribriform prostate cancer aggressiveness remain to be explored. Here, the authors perform single-cell RNA-sequencing, TCR sequencing and histology and reveal cancer cell intrinsic pathways and an immunosuppressive tumour microenvironment.
