Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

Abstract

The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.

Keywords

• HTLV-1
• Tax
• retrovirus
• signal transduction
• NF-kB
• nuclear bodies
• intracellular trafficking
• posttranslational modifications
• leukemia