Nature Communications (Nov 2020)
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
- Robbert Boudewijns,
- Hendrik Jan Thibaut,
- Suzanne J. F. Kaptein,
- Rong Li,
- Valentijn Vergote,
- Laura Seldeslachts,
- Johan Van Weyenbergh,
- Carolien De Keyzer,
- Lindsey Bervoets,
- Sapna Sharma,
- Laurens Liesenborghs,
- Ji Ma,
- Sander Jansen,
- Dominique Van Looveren,
- Thomas Vercruysse,
- Xinyu Wang,
- Dirk Jochmans,
- Erik Martens,
- Kenny Roose,
- Dorien De Vlieger,
- Bert Schepens,
- Tina Van Buyten,
- Sofie Jacobs,
- Yanan Liu,
- Joan Martí-Carreras,
- Bert Vanmechelen,
- Tony Wawina-Bokalanga,
- Leen Delang,
- Joana Rocha-Pereira,
- Lotte Coelmont,
- Winston Chiu,
- Pieter Leyssen,
- Elisabeth Heylen,
- Dominique Schols,
- Lanjiao Wang,
- Lila Close,
- Jelle Matthijnssens,
- Marc Van Ranst,
- Veerle Compernolle,
- Georg Schramm,
- Koen Van Laere,
- Xavier Saelens,
- Nico Callewaert,
- Ghislain Opdenakker,
- Piet Maes,
- Birgit Weynand,
- Christopher Cawthorne,
- Greetje Vande Velde,
- Zhongde Wang,
- Johan Neyts,
- Kai Dallmeier
Affiliations
- Robbert Boudewijns
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Hendrik Jan Thibaut
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Suzanne J. F. Kaptein
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Rong Li
- Department of Animal, Dairy, and Veterinary Sciences, Utah State University
- Valentijn Vergote
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Laura Seldeslachts
- KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC
- Johan Van Weyenbergh
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Carolien De Keyzer
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Lindsey Bervoets
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Sapna Sharma
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Laurens Liesenborghs
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Ji Ma
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Sander Jansen
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Dominique Van Looveren
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Thomas Vercruysse
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Xinyu Wang
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Dirk Jochmans
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Erik Martens
- Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Kenny Roose
- VIB-UGent Center for Medical Biotechnology, VIB
- Dorien De Vlieger
- VIB-UGent Center for Medical Biotechnology, VIB
- Bert Schepens
- VIB-UGent Center for Medical Biotechnology, VIB
- Tina Van Buyten
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Sofie Jacobs
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Yanan Liu
- Department of Animal, Dairy, and Veterinary Sciences, Utah State University
- Joan Martí-Carreras
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Bert Vanmechelen
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Tony Wawina-Bokalanga
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Leen Delang
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Joana Rocha-Pereira
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Lotte Coelmont
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Winston Chiu
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Pieter Leyssen
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Elisabeth Heylen
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Dominique Schols
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Lanjiao Wang
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Lila Close
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Jelle Matthijnssens
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Marc Van Ranst
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Veerle Compernolle
- Blood Service, Belgian Red Cross Flanders
- Georg Schramm
- KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC
- Koen Van Laere
- KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC
- Xavier Saelens
- VIB-UGent Center for Medical Biotechnology, VIB
- Nico Callewaert
- VIB-UGent Center for Medical Biotechnology, VIB
- Ghislain Opdenakker
- Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Piet Maes
- Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Birgit Weynand
- KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research
- Christopher Cawthorne
- KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC
- Greetje Vande Velde
- KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC
- Zhongde Wang
- Department of Animal, Dairy, and Veterinary Sciences, Utah State University
- Johan Neyts
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- Kai Dallmeier
- Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation
- DOI
- https://doi.org/10.1038/s41467-020-19684-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.
